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Figure 3 | BMC Systems Biology

Figure 3

From: Network features suggest new hepatocellular carcinoma treatment strategies

Figure 3

Redundant paths between the crosstalk of MAPK and focal adhesion pathways. (A) The sub-network of pathways that engage in crosstalk with either the MAPK pathway or the Focal Adhesion pathway are shown in yellow. Among them, pathways that are targeted by the drug sorafenib are red, pathways with the highest node degree (the first 8 hubs, see list in FigureĀ 4A) are blue, and the immune system pathways (with highest node degree, see list in FigureĀ 4A) are green. The 63 redundant 3-node circles included in this crosstalk highlight the complexity of targeting this crosstalk with an indirect approach, but on the other hand indicate its importance due to the many regulators, among them being the hubs, the immune system, and pathways targeted by sorafenib. (B) The redundant 3-node circles can be grouped based on their pathway categories (category shown in magenta), so a more compact meaningful representation of those circles can be written: instead of 63 pathway circles, we have 23 category circles. For example, 9 of the 3-node circles are from the Infectious Diseases category, and 6 others are from the Immune System category. (C) All pathway categories with degree above 1.

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