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Table 1 Equations for the caspase3 channel in Figure 1 a

From: Quantitative analysis of intracellular communication and signaling errors in signaling networks

  Molecules Equations
Internal molecules of the channel (listed alphabetically) 1. AKT AKT = EGFR + insulin
2. caspase8 caspase8 = cFLIPL’ × (ComplexII + ERK)
3. cFLIPL cFLIPL = NFκB
4. ComplexI ComplexI = TNF
5. ComplexII ComplexII = TNF + ComplexI
6. EGFR EGFR = EGF
7. ERK ERK = MEK
8. IKK IKK = ComplexI
9. IRS1 IRS1 = Insulin
10. JNK1 JNK1 = MKK7
11. MEK MEK = EGFR + IRS1
12. MEKK1ASK1 MEKK1ASK1 = ComplexI
13. MK2 MK2 = p38
14. MKK3 MKK3 = MEKK1ASK1
15. MKK7 MKK7 = MEKK1ASK1
16. NFκB NFκB = IKK
17. p38 p38 = MKK3
Channel output caspase3 caspase3 = AKT’ × (caspase8 + JNK1 + MK2)
  1. Each equation specifies the input signals to a molecule using the binary operations ’, + and ×, which represent NOT, OR and AND, respectively.