Quantitative analysis of intracellular communication and signaling errors in signaling networks

BMC Systems Biology

Table 1 Equations for the caspase3 channel in Figure 1 a

	Molecules	Equations
Internal molecules of the channel (listed alphabetically)	1. AKT	AKT = EGFR + insulin
	2. caspase8	caspase8 = cFLIP_L’ × (ComplexII + ERK)
	3. cFLIP_L	cFLIP_L = NFκB
	4. ComplexI	ComplexI = TNF
	5. ComplexII	ComplexII = TNF + ComplexI
	6. EGFR	EGFR = EGF
	7. ERK	ERK = MEK
	8. IKK	IKK = ComplexI
	9. IRS1	IRS1 = Insulin
	10. JNK1	JNK1 = MKK7
	11. MEK	MEK = EGFR + IRS1
	12. MEKK1ASK1	MEKK1ASK1 = ComplexI
	13. MK2	MK2 = p38
	14. MKK3	MKK3 = MEKK1ASK1
	15. MKK7	MKK7 = MEKK1ASK1
	16. NFκB	NFκB = IKK
	17. p38	p38 = MKK3
Channel output	caspase3	caspase3 = AKT’ × (caspase8 + JNK1 + MK2)

Each equation specifies the input signals to a molecule using the binary operations ’, + and ×, which represent NOT, OR and AND, respectively.

ISSN: 1752-0509