Total computation time for model subaa using different combination (or randomized) of parallelization. (A) The tCPU for 100 tests using randomized reaction order, sorted in the order of increasing tCPU, are shown with dashed line. The tCPU for all 256 combinations of constraining none, some or all of the 8 reversible basis vectors are shown. The bottom horizontal axis denotes the number of constrained basis vectors in a given combination. (B) The differences in tCPU are shown as a result of sorting reaction rows according to the number of possible combination between the positive and negative elements within a row, compared to the original unsorted configuration.