Table 2 Similarities and differences between ISL and ISHC
From: Toward modular biological models: defining analog modules based on referent physiological mechanisms
| Â | ISL | ISHC |
|---|---|---|
Referent system | In situ isolated, perfused rat liver | In vitro rat hepatocyte culture |
Targeted attribute | Outflow profile | Intrinsic clearance |
Similarity criteria | 80% of points fall within band of ±1 standard deviation of wet-lab value | Value falls within ±1 standard deviation of wet-lab value; r 2 > 0.95 |
Structure | Concentric, cylindrical grids within sinusoidal network | Stacked, two-dimensional, rectangular grid system |
Time scale | ~Seconds/minutes | ~Minutes/hours |
Test drug | Propranolol | Propranolol |
Physiomimetic mechanism modules used | InductionHandler, EliminationHandler, MetabolismHandler, BindingHandler | InductionHandler, EliminationHandler |
MetabolismHandler, BindingHandler |