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Table 2 Similarities and differences between ISL and ISHC

From: Toward modular biological models: defining analog modules based on referent physiological mechanisms

  ISL ISHC
Referent system In situ isolated, perfused rat liver In vitro rat hepatocyte culture
Targeted attribute Outflow profile Intrinsic clearance
Similarity criteria 80% of points fall within band of ±1 standard deviation of wet-lab value Value falls within ±1 standard deviation of wet-lab value; r 2 > 0.95
Structure Concentric, cylindrical grids within sinusoidal network Stacked, two-dimensional, rectangular grid system
Time scale ~Seconds/minutes ~Minutes/hours
Test drug Propranolol Propranolol
Physiomimetic mechanism modules used InductionHandler, EliminationHandler, MetabolismHandler, BindingHandler InductionHandler, EliminationHandler
MetabolismHandler, BindingHandler