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Table 3 Relevant ISHC parameters and corresponding in silico intrinsic clearance values among validating runs

From: Toward modular biological models: defining analog modules based on referent physiological mechanisms

  Griffin and Houston[[33]] Lavé et al.[[52]]
(CL= 8.9 ± 4.2 μL/min/106cells) (CL= 51.0 μL/min/106cells)
Experiment number 1 2 3 4 5 6
pExitMedia 0.02 0.02 0.03 0.2 0.18 0.2
pExitCell 1.0 1.0 1.0 1.0 1.0 0.85
pBind 0.25 0.25 0.25 0.25 0.5 0.5
pMetabolize 0.5 0.25 0.25 0.5 0.5 0.5
dosage 10000 10000 10000 10000 10000 10000
CL (μL/min/10 6 cells) 9.59 ± 0.22 8.71 ± 0.34 12.82 ± 0.43 48.53 ± 0.79 48.36 ± 0.64 53.30 ± 0.94