Skip to main content
Figure 1 | BMC Systems Biology

Figure 1

From: Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer

Figure 1

Common gene fusions in cancer biology. Different mechanisms of gene fusions in cancer are shown. Figure 1 (a) Shows the mechanisms of oncogenic transcription factor activation by means of an endogenous enhancer. Figure 1 (b) Shows an example of disrupting gene fusion where the 5’ gene leads to the deregulation of the 3’ tumor suppressor gene. Finally, Figure 1 (c) and 1 (d) depicts the BCR-ABL1, NPM1-ALK and FGFR3-TACC3 chimeras where a completely new protein is produced.

Back to article page