Common gene fusions in cancer biology. Different mechanisms of gene fusions in cancer are shown. Figure 1
(a) Shows the mechanisms of oncogenic transcription factor activation by means of an endogenous enhancer. Figure 1
(b) Shows an example of disrupting gene fusion where the 5’ gene leads to the deregulation of the 3’ tumor suppressor gene. Finally, Figure 1
(c) and 1
(d) depicts the BCR-ABL1, NPM1-ALK and FGFR3-TACC3 chimeras where a completely new protein is produced.