Table 1 Initial conditions and rate coefficient values

IGFBPs per cell^a

1.21 × 10⁻⁸ nmol/cell

IGF1R per cell^a

2.23 × 10⁻¹¹ nmol/cell

Reference cell number N ₀ ^a

116,000 cells/well

Rate coefficient

Value

Association rate coefficient of IGF1-IGF1R complex (k ₁ )^b

1 nM⁻¹ hr⁻¹

Dissociation rate coefficient of IGF1 and IGF1R (k ₋₁ )^b

1 hr⁻¹

Association rate coefficient of IGF1-IGFBP complex (k ₂ )^b

1 nM⁻¹ hr⁻¹

Dissociation rate coefficient of IGF1 and IGFBP (k ₋₂ )^b

0.1 hr⁻¹

Cell-mediated IGF1 depletion rate coefficient (k _3,0 )^a

0.017 hr⁻¹