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Table 1 Initial conditions and rate coefficient values

From: Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy

Initial condition Value
IGFBPs per cella 1.21 × 10−8 nmol/cell
IGF1R per cella 2.23 × 10−11 nmol/cell
Reference cell number N 0 a 116,000 cells/well
Rate coefficient Value
Association rate coefficient of IGF1-IGF1R complex (k 1 )b 1 nM−1 hr−1
Dissociation rate coefficient of IGF1 and IGF1R (k −1 )b 1 hr−1
Association rate coefficient of IGF1-IGFBP complex (k 2 )b 1 nM−1 hr−1
Dissociation rate coefficient of IGF1 and IGFBP (k −2 )b 0.1 hr−1
Cell-mediated IGF1 depletion rate coefficient (k 3,0 )a 0.017 hr−1
  1. aExperimentally determined for OVCAR5 cells.
  2. bBased on K d = 1 nM for IGF1 with IGF1R and K d = 0.1 nM for IGF1 with IGFBPs [24],[26],[87]–[94].