Visual Representation of repeated (6×) Stress Network. Left panel: The rat adrenal medulla 6× IMO network contains 1313 genes/proteins (nodes) and 5203 interactions (edges). Genes/proteins that are first neighbors of Egr1 were identified with Cytoscape and are in green. Right panel: Visual representation of the 6× IMO network edges (black lines) link nodes (proteins/genes represented by open squares). The Egr1 neighborhood is shown in the right panel with first neighbors of Egr1 in each motif (extracted with Cytoscape) shown in yellow and green. The nearest neighbors of Egr1 and their shortest paths were calculated within the HUBBA website with Djikstra’s algorithm and re-displayed with Cytoscape. The arrows next to gene names indicate changed expression in 6× samples.