A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress

Table 3 KEGG and GO pathways of top 5 Cytoscape modules in 6× IMO network

	Sub-network motif 1	Sub-network motif 2	Sub-network motif 3	Sub-network motif 4	Sub-network motif 5
KEGG pathway	Insulin signaling pathway	Purine metabolism	Purine metabolism	Focal adhesion	Pyrimidine metabolism
	Focal adhesion	Purine metabolism	Purine metabolism	MAPK signaling pathway	Purine metabolism
	Regulation of actin cytoskeleton	Purine metabolism	Purine metabolism	MAPK signaling pathway	Pyrimidine metabolism
	TGF-beta signaling pathway	Pyrimidine metabolism	Pyrimidine metabolism	Jak-STAT signaling pathway	Purine metabolism
GO pathway	Protein biosynthesis	Cyclic nucleotide biosynthesis	cGMP metabolism	Morphogenesis	Nucleoside diphosphate metabolism
	Macromolecule biosynthesis	Cyclic nucleotide metabolism	cGMP biosynthesis	Development	Pyrimidine base metabolism
	Cellular biosynthesis	Nucleotide biosynthesis	Transcription initiation	Organogenesis	Deoxyribonucleoside diphosphate metabolism
	Biosynthesis	Nucleotide metabolism	Nucleobase, nucleoside, nucleotide	Organ development	Nucleotide metabolism

ISSN: 1752-0509