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Figure 8 | BMC Systems Biology

Figure 8

From: Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model

Figure 8

Overrepresentation of active cofilin between pillars due to (de-)activation mechanism tied to the focal adhesion complex. (Rate parameter names related to CofReg, rCofRegAppearance and rCofRegDissapearance slightly shortened). A: The fraction of cofilin that is active is higher in the region between surface structures than on surface structures (all points are above the dotted line, where both would be equal). B: The fraction of cofilin that is located on pillars (x-axis) is often slightly lower than the pillars’ share of the system size (29.7%), but unrelated to the difference in activity ratios of cofilin between the respective regions (note that each marker’s position on the y-axis corresponds to the respective markers’ distance from the dotted line in the left panel).

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