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Table 2 Parameters and results of simulation runs shown in Figure 9

From: Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model

Figure 9 panel Top left Top right Bottom left Bottom right
rCofRegAppearance 2.0 2.0 0.5 0.5
rCofRegDisappearance 0.5 0.5 2.0 2.0
Angle deviation N 0 , 1 5 ° 2 N 0 , 15 2 N 0 , 30 2 N 0 , 30 2
Cofilin / total active on pillars 0.028 0.021 0.22 0.26
between pillars   0.141   0.38
Average filament length (# particles) 21.1 18.5 13.0 11.4
Maximum filament length (# particles) 69 58 29 33
  1. All four runs had these parameter values in common: initial actin amount 500 (changes here did not significantly change the results as most actin was “produced” during the simulation), integrin amount 200 (a lower amount, 100, lead to 20% longer filaments in situations where cofilin activity was low, ie corresponding to the top panels), cofilin amount 800 (lower values lead slightly longer filaments in all four settings).