Identified network signatures. Network signatures of the top relevance scores representing the centrality of the node in linking the three interventions with disease parameters through co-expression modules A, B, and C. A) The signatures for DLI (left bar) and corresponding relevance scores for fenofibrate (FF) and T0901317 (T09) (right bars). B) The signatures for fenofibrate (FF, left bar) and corresponding relevance scores for DLI and T0901317 (T09) (right bars). C) The signatures for T0901317 (T09, left bar) and corresponding relevance scores for DLI and fenofibrate (FF) (right bars). Each signature contains the union of the top 10 genes with highest relevance scores for connecting the intervention targets to genes from either module A, B, or C. Each column in the heatmap represents the relevance scores for the paths to a module, each row represents a gene in the network. The genes are sorted by the maximum of the relevance scores across the signatures for module A, B, and C. Cells are shaded by relevance score (darker is a higher relevance score) and colored by direction of regulation by the intervention (red is upregulated, blue is downregulated). Colored boxes left of the gene symbols indicate for each gene the co-expression module membership. Colored asterisks on the right of the gene symbols indicate when the gene was considered as intervention target).