Metabolic fluxes (nmol.mL-1.min-1) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Incubation condition | |||||||||
Ins - | Ins + | ||||||||
Flux num | Flux reaction | Res - | Res + | Res - | Res + | ||||
Median | [min-max] | Median | [min-max] | Median | [min-max] | Median | [min-max] | ||
0 | Glucose phosphorylation | 1.500 | [1.500-1.500] | 1.700** | [1.700-1.700] | 2.300** | [2.300-2.300] | 1.975†† | [1.975-1.975] |
Glycolytic and PPP fluxes: | |||||||||
1 | Phosphofructokinase | 1.674 | [1.442-3.004] | 2.018 | [1.679-2.586] | 2.664* | [2.537-2.670] | 1.907 | [1.874-1.919] |
2 | Oxidative branch of PPP | 0.199 | [0.196-0.199] | 0.200 | [0.198-0.200] | 0.248** | [0.246-0.298] | 0.198 | [0.192-0.199] |
3 | Pyruvate kinase | 3.078 | [3.026-3.262] | 3.582 | [2.644-4.126] | 4.671** | [4.573-4.873] | 4.337 | [4.087-4.468] |
Glycogen-related fluxes: | |||||||||
4 | Glycogen phosphorylase | 0.038 | [0.034-0.052] | 0.034 | [0.024-0.066] | 0.043 | [0.037-0.046] | 0.032 | [0.029-0.035] |
5 | Glycogen synthase | 0.040 | [0.036-0.053] | 0.035 | [0.024-0.067] | 0.050 | [0.043-0.058] | 0.038 | [0.034-0.040] |
Pyruvate homeostasis-related fluxes: | |||||||||
6 | Pyruvate dehydrogenase complex | 1.511 | [1.421-1.843] | 2.354** | [2.118-2.363] | 2.479* | [1.785-2.987] | 2.125 | [1.575-2.494] |
7 | Pyruvate carboxylase | 0.200 | [0.113-0.291] | 0.117 | [0.027-0.201] | 0.197 | [0.155-0.254] | 0.031 | [0.028-0.055] |
8 | Lactate dehydrogenase | 1.366 | [1.292-1.451] | 1.511 | [1.446-1.654] | 2.033** | [1.620-2.738] | 2.192†† | [1.722-2.739] |
9 | Pyruvate cycling | 0.228 | [0.200-0.377] | 0.474 | [0.222-0.884] | 0.296 | [0.264-0.389] | 0.538 | [0.303-0.594] |
Tricarboxylic acid cycle fluxes: | |||||||||
10 | Citrate synthase | 0.022 | [0.019-0.386] | 0.012 | [0.001-0.023] | 0.099 | [0.022-0.172] | 0.009 | [0.002-0.037] |
11 | Citrate ->Malate | 0.035 | [0.032-0.462] | 0.072 | [0.050-0.400] | 0.185 | [0.110-0.298] | 0.370 | [0.082-0.395] |
12 | Malate ->OAA | 0.640 | [0.481-2.088] | 1.152 | [0.453-3.104] | 1.509 | [0.780-2.413] | 2.078 | [0.477-3.095] |
13 | OAA -> Malate | 0.605 | [0.446-1.776] | 1.080 | [0.294-2.800] | 1.324 | [0.668-2.115] | 1.708 | [0.336-2.773] |
14 | Acetyl-CoA output | 1.489 | [1.313-1.625] | 2.344** | [2.114-2.355] | 2.380** | [1.760-2.851] | 2.116 | [1.565-2.485] |