Figure 7

DevR regulon. A) Left: Histogram in blue represents the correlation among all the genes present in our compendium, whereas the histogram in green is based upon the correlations of the identified targets for which expression data is available within our compendium (605). Both show the same overall distribution. Right: Histogram in blue represents the correlation among all the genes present in our compendium, whereas the histogram in green is based upon the correlations of the 107 genes selected in the core set. Note there is a shift towards positive correlation values, pointing to a common regulatory influence over the selected genes. B) Number of genes identified in the DevR regulon compared to the number of targets identified through ChIP-seq experiments or the ones cited in literature [32],[76][78]. C) Group assignment of the 622 targets identified by ChIP-seq for DevR. G0 contains genes for which non discernible expression pattern has been found. G1 correspond to the usually named DevR regulon, whereas G2-4 contains genes that show correlated expression patterns, although these patterns are not consistent with the previously described behaviour of DevR regulon. A detailed list of these genes is available in Additional file 12 and the output of the GO-enrichment analysis is shown in Additional file 16.