Figure 8
ZuR regulon. A) Bicluster formed by members of the ZuR as reported in literature [81]. The grey line represents the average expression levels of the members of ZuR regulon in the conditions in our compendium. The numbers identify the 23 conditions that have been included in the bicluster. The horizontal bar and the different regions indicated by numbers refer to the classification of the conditions as described in Materials and Methods. Notice the clear up-regulation of this set in conditions of type 9: Transcription inhibition, in particular these values correspond to experiments were Rifapentine was added to the medium. For clarity, expression values have been scaled, so that the mean value for each gene when all conditions are considered is zero. B) Identified ZuR binding motif. E-value 4.2*1049. C) Number of genes in the ZuR regulon (Additional file 17) compared to the ones previously identified [81], the set anticorr. contains Rv0232 and lpqR, that show anticorrelation with the rest of the genes in the regulon.