Table 1 Hub proteins identified in the zebrafish intracellular PPI network for primary infection
Rank | Zebrafish protein | Degree | GO functional annotation |
|---|---|---|---|
1 | Tfap2a | 10 | Regulation of cell differentiation |
2 | Gch2 | 10 | Response to interferon γ |
3 | Hsp90a.1 | 10 | Fc-γ receptor signaling |
4 | Acvr1b | 9 | TGF-β receptor activity |
5 | Btg2 | 9 | Negative regulation of cell proliferation |
6 | Cct5 | 9 | Response to virus |
7 | Clock | 9 | Circadian rhythm |
8 | Fkbp5 | 9 | Heat shock protein binding |
9 | Fos | 9 | Innate immune response |
10 | Ncstn | 9 | T cell proliferation |