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Figure 1 | BMC Systems Biology

Figure 1

From: A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors

Figure 1

Example of biding site similarities between the modelled asd gene product and the photosynthetic a2b2-glyceraldehyde-phosphate dehydrogenase bound to NADP. The two binding-sites share 39 atoms of equivalent atom types in corresponding positions in space (Z-score 3.92, p-value 0.012). This protein from spinach (PDB ID 2PKQ) belongs to Pfam family PF00044 that contain human homologs. The inset shows the superimposition of the bound NADP molecules found among 5 of the top 7 most similar binding-sites belonging to different protein families.

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