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Table 2 Comparison between the automatic C. difficile , i MLTC806cdf and C. acetobutylicum networks

From: A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors

Characteristic Automatic network iMLTC806cdf C. acetobutylicum iCAC490
Reactions 3211 914 740
With genes 1311 (40.8%) 706 (77.9%) 490 (66.2%)
With an EC number 1435 (44.7%) 750 (82.1%) 649 (87.7%)
With KEGG ID 1038 (32.3%) 703 (76.9%) 652 (88.4%)
Identified as unclear reaction 4 (0.4%) 0 2 (0.2%)
Associated with multiple reactions 84 (8.1.6%) 6 (0.7%) 0
Involving polymers 26 (0.8%) 0 0
Involving generic metabolites 548 (29.8%) 31 (3.4%) 44 (5.9%)
Non-metabolic reactions 138 (4.3%) 2 (0.2%) 15 (2.0%)
Involving oxygen 29 (0.9%) 0 -b
Transport reactions 1576 (49.1%) 145 (15.9%) 66 (8.9%)
Export 1562 (99.1%) 16 (11.0%) 3 (4.5%)
Passive 14 (0.9%) 15 (10.3%) 11 (16.7%)
with genes 0 95 (65.5%) 43 (65.15%)
Unique reactions in common   530   416  
Metabolites 3133 705 709
Unique 1551 592 654
With KEGG ID 1092 (70.4%) 563 (94.9%) 613 (93.7%)
Generic 485 (31.3%) 23 (3.9%) 50 (7.6%)
Duplicated 15 (1.0%) 0 0
Dead-end 648 (41.8%) 8 (1.2%) 186 (28.4%)
Unique metabolites in common   533   389  
Genes 1336 806 490
Unique loci 788 806 490
With a homologa 788 (100%) 658 (81.8%) 417 (85.1%)
Non-metabolic loci 66 (8.4%) 3 (0.4%) 11 (2.2%)
Loci linked to multiple entries 382 (48.5%) 0   0
Unique loci in common   534   350  
  1. aThe values in the first and last columns represent the number of homologs with respect to i MLTC806cdf. The values in the middle column represent the number of homologs with respect to C. acetobutylicum.
  2. bReactions involving oxygen are allowed in C. acetobutylicum thus were not quantified.