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Table 2 Comparison between the automatic C. difficile , i MLTC806cdf and C. acetobutylicum networks

From: A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors

Characteristic

Automatic network

iMLTC806cdf

C. acetobutylicum iCAC490

Reactions

3211

914

740

With genes

1311 (40.8%)

706 (77.9%)

490 (66.2%)

With an EC number

1435 (44.7%)

750 (82.1%)

649 (87.7%)

With KEGG ID

1038 (32.3%)

703 (76.9%)

652 (88.4%)

Identified as unclear reaction

4 (0.4%)

0

2 (0.2%)

Associated with multiple reactions

84 (8.1.6%)

6 (0.7%)

0

Involving polymers

26 (0.8%)

0

0

Involving generic metabolites

548 (29.8%)

31 (3.4%)

44 (5.9%)

Non-metabolic reactions

138 (4.3%)

2 (0.2%)

15 (2.0%)

Involving oxygen

29 (0.9%)

0

-b

Transport reactions

1576 (49.1%)

145 (15.9%)

66 (8.9%)

Export

1562 (99.1%)

16 (11.0%)

3 (4.5%)

Passive

14 (0.9%)

15 (10.3%)

11 (16.7%)

with genes

0

95 (65.5%)

43 (65.15%)

Unique reactions in common

 

530

 

416

 

Metabolites

3133

705

709

Unique

1551

592

654

With KEGG ID

1092 (70.4%)

563 (94.9%)

613 (93.7%)

Generic

485 (31.3%)

23 (3.9%)

50 (7.6%)

Duplicated

15 (1.0%)

0

0

Dead-end

648 (41.8%)

8 (1.2%)

186 (28.4%)

Unique metabolites in common

 

533

 

389

 

Genes

1336

806

490

Unique loci

788

806

490

With a homologa

788 (100%)

658 (81.8%)

417 (85.1%)

Non-metabolic loci

66 (8.4%)

3 (0.4%)

11 (2.2%)

Loci linked to multiple entries

382 (48.5%)

0

 

0

Unique loci in common

 

534

 

350

 
  1. aThe values in the first and last columns represent the number of homologs with respect to i MLTC806cdf. The values in the middle column represent the number of homologs with respect to C. acetobutylicum.
  2. bReactions involving oxygen are allowed in C. acetobutylicum thus were not quantified.