Figure 4

Sexually-dimorphic targeting of biological functions in Sputum and Blood networks. (A) All GO categories significantly differentially-targeted (FDR < 0.01) using a GSEA-type approach to compare gene targeting in male and female networks derived from either sputum or blood expression data. Many functional categories have genes that appear to be much more highly targeted in the female networks compared to the male networks. There is a high level of agreement between the differential-targeted GO categories in both the sputum and blood networks, but the enrichment disappears in the “random” networks. (B) The ten most differentially-targeted pathways enriched in the female and the male sputum networks.