Figure 5

Transcription-factor differential-targeting of biological functions. (A) A hierarchical clustering of the t-statistic associated with differential edge weight between ensembles of female and male sputum networks. Each point in the matrix represents the t-statistic of an individual edge extending from a transcription factor (column) to a gene (row) (B-C) The statistical enrichment of GO categories in genes differentially-targeted by a transcription factor between male and female (B) sputum and (C) blood networks. All categories significantly (FDR < 0.01) differentially-targeted by at least one of the transcription factors, in the given tissue-type, is shown. The columns (transcription factors) are ordered identically to the hierarchical clustering in (A) and we observe a strong correlation with the transcription-factor differential-targeting of GO categories in (B). Although there is some similarity in the transcription-factor differential-targeting of these functional sets of genes in the sputum and blood networks, there is overall less enrichment in the blood comparison.