Figure 6

Identifying disease-specific drivers of sexually-dimorphic functional targeting. (A) Sputum (top panel) and blood (bottom panel) transcription-factor specific enrichment for differential-targeting of the top five GO functions identified in either males or females in Figure 4B. (B) A distribution of the similarity between differential-targeting patterns of transcription factors in sputum and blood network, as measured using the Spearman correlation. A red line indicates the cutoff used to identify transcription factors that have opposite sex-specific regulatory patterns in sputum compared to blood networks. (C-G) Plots comparing individual transcription factors’ sex-specific differential-targeting of these GO functions (five in female, filled shapes, and five in male, hollow shapes) in the sputum versus the blood networks.