Figure 7

Illustrations of core subnetworks of sex-specific regulation in COPD. (A) The sputum subnetwork, defined by sputum sex-specific edges (as shown in Figure 2B) that extend between the identified disease-specific drivers (Figure 6B) and genes annotated to one of the top five differentially-targeted GO categories in ensembles of networks built based on sputum expression data (Figures 4B and 6). (B) The blood subnetwork, defined by blood sex-specific edges (Figure 2C) that extend between the identified disease-specific drivers (Figure 6B) and genes annotated to top five GO categories identified as differentially-targeted between male and female networks (Figures 4B and 6). Edges and genes are colored pink or blue based on whether they were identified as part of the female or male networks or functions, respectively.