Figure 5

The space-induced bifurcation depends on kinetics parameters (2D simulations). The average value of the first zero crossing of the ACF (FZCA) is reported as a function of the mRNA degradation rate 1/τ _M (A) or the number of gene copy G _T (B) for uniform (black circles), clustered (brown circles) or segregated (magenta circles) gene configurations. For each value of parameters and each gene configuration, 20 simulations were run. Circles are the average of the 20 resulting FZCA and bars ± 1 s.d. In both panels, the horizontal coordinates are shifted for readability. Labels (a), (b) and (c) locate the parameters used to generate the corresponding subpanels of Figure 3, while labels (a'), (b'),(c') and (a'), (b'),(c') refer to the examples shown in Additional file 1: Figure S1 (a"), (b") and (c") and Additional file : Figure S2 (a”’), (b”) and (c”), respectively, in the Supporting Material. Wherever applicable (i.e. except for the uniform configuration), the size of the internal boxes was r=3. All other parameters were according to the standard set defined in the Methods section.