Table 3 Description of workflows implemented in MetaNET

Automated Flux Balance Analysis Workflow

Used to perform FBA of metabolic network using default objective function

6

Customized Flux Balance Analysis Workflow

Used to perform FBA of metabolic network using user-defined objective function

5

Gene Essentiality Workflow

Used to investigate lethal genes

8

Reaction Essentiality Workflow

Used to investigate lethal reactions

7

Catalyst Essentiality workflow

Used to investigate lethal catalysts

8

Pairwise Genes knock-out Workflow

Used to knock-out genes pairwise

8

Pairwise Reactions knock-out Workflow

Used to knock-out reactions pairwise

8

Pairwise Catalysts knock-out workflow

Used to knock-out catalysts pairwise

8