Figure 1

PCA of docetaxel perturbations highlights the different metabolic responses of OCCs and OCSCs. PCA of metabolic profiles of OCCs (A) and OCSCs (B) in response to docetaxel over 48 hours. Dotted ovals represent 95% confidence intervals of the membership of each sample class. (A) PCA shows clear separation between control and docetaxel treated OCCs, as well as separation between the two treatment levels, and separation between the time points for all treatments and controls. PC1 and PC2 both are responsible for the separation between different experimental groups as well as time. (B) PC1 separates the initial time point and the later time points, but there is no separation between control and docetaxel treated cells, suggesting that docetaxel has little to no effect on the metabolism of OCSCs over a 48 hour period.