Prediction of signaling cross-talks contributing to acquired drug resistance in breast cancer cells by Bayesian statistical modeling

Table 3 Comparative results between primary dataset (SKBR3 cell-line, GSE38376) and validation dataset (BT474 cell-line, GSE16179)

Pathway name	Found in Pathway source	Found in Pathway source	Common cross-talks in both Studies ^¶
	(GSE38376)	(GSE16179)
Notch Signaling	Reactome,	Reactome,	MAP2K4::NOTCH1
	KEGG,	KEGG,
	WikiPathway	WikiPathway
GPCR signaling	Reactome,	Reactome,	*CBL::TSHR*
	WikiPathway	WikiPathway	FGFR1::TSHR
			*PDGFRA::GNAQ*
			*KIT::TSHR*
			LCK::TSHR
			MDM2::TSHR
			*PDGFRA::TSHR*
WNT Signaling	Reactome,	Reactome,	AKT2::CCND2
	KEGG,	KEGG,	MAP2K4::CCND2
	WikiPathway	WikiPathway	MAP2K4::TP53
			MDM2::MAP2K4
Insulin (IGF1R) Signaling	Reactome,	Reactome,	MDM2::MAP2K4
	WikiPathway	WikiPathway	TP53::MAP2K4
TGF- β Signaling	Reactome,	Reactome,	MDM2::TFE3
	WikiPathway	KEGG,	TP53::TFE3
		WikiPathway
MAPK signaling	KEGG,	KEGG,	MDM2::MAP2K4
	WikiPathway	WikiPathway

^¶These common cross-talks were found using the primary dataset (104, 188 and 299 cross-talks from Reactome, KEGG and WikiPathway databases, respectively) and validation datasets (83, 133 and 277 cross-talks from Reactome, KEGG and WikiPathway databases, respectively). Cross-talks mentioned with Bold face are those consistent with our hypothesis that both genes in the particular cross-talk are up-regulated in resistant conditions but down-regulated in parental conditions.

ISSN: 1752-0509