Figure 1

Structure of the granulopoiesis model under chemotherapy and G-CSF treatment. Boxes represent major cell- or cytokine compartments of the model: S = haematopoietic stem cells, CG = granulopoietic progenitors, PGB = granulopoietic precursors, MGB = maturing granulopoietic precursors in bone marrow, GRA = mature granulocytes in blood, LY = lymphocytes. We modelled two G-CSF derivatives (fil = Filgrastim, peg = Pegfilgrastim). Arrows represent cell/cytokine fluxes and interactions. CX represents the strength of chemotherapy (see below).