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Figure 5 | BMC Systems Biology

Figure 5

From: Modelling chemotherapy effects on granulopoiesis

Figure 5

Simulation results of selected complex chemotherapies. We present results for the two breast cancer therapies, EC-T and ETC with Filgrastim on days 3–10 (first row). Note that in these schedules, chemotherapeutic drugs differ between cycles: For EC-T the drugs epirubicine and cyclophosphamide where applied in combination in the first four cycles. The single drug paclitaxel was applied for the last four cycles. For ETC, the single drug epirubicine was applied in three cycles followed by three cycles of paclitaxel and three cycles of cyclophosphamide. We also present two therapies of advanced Hodgkin’s lymphoma, BEACOPP-21 and BEACOPP escalated with Filgrastim on days 8–15, in which multiple drugs are administered at different time points per cycle (second row). Dosages can be found in Table 1. Dots represent patient medians, grey lines represent interquartile range of patient data, squares represent chemotherapy administrations, “+” denote G-CSF-injections.

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