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Figure 6 | BMC Systems Biology

Figure 6

From: Modelling chemotherapy effects on granulopoiesis

Figure 6

Correlation of stem cell toxicity and peripheral toxicity. We determined cumulative toxicities of stem cells and mature blood cells for each drug or drug combination considered. Toxicities are expressed in terms of AOC of normalized cell counts applying the steady-state value 1 as threshold. AOC is calculated over 28 days. Only a single injection of chemotherapy was simulated for this purpose. The unit of AOC is “d”. A good correlation between stem cell and peripheral toxicity can be observed (Spearman’s r = 0.88). Toxicity relations between schedules are plausible. Note that schedules may be attributed to different groups of patients.

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