Modelling chemotherapy effects on granulopoiesis

Schirm, Sibylle; Engel, Christoph; Loeffler, Markus; Scholz, Markus

doi:10.1186/s12918-014-0138-7

BMC Systems Biology

Table 2 Clinical data sets used for modelling: we present disease, chemotherapy protocol and corresponding G-CSF schedules

From: Modelling chemotherapy effects on granulopoiesis

	G-CSF derivative	Administration	Disease	Chemotherapy	Reference
01	Filgrastim	5 μg/kg, days 2-13	Breast cancer	TA	[32]
02	Filgrastim	5 μg/kg, days 2-6	NSCLC	CP	[33]
03	Filgrastim	480 μg/kg, days 6-13	NHL	high-CHOEP-14*	[34]
04	Pegfilgrastim	30 μg/kg, day 2	Breast cancer	TA	[32]
05	Pegfilgrastim	60 μg/kg, day 2	Breast cancer	TA	[32]
06	Pegfilgrastim	100 μg/kg, day 2	Breast cancer	TA	[32]
07	Pegfilgrastim	6000 μg/kg, day 2	Breast cancer	TA	[35]
08	Pegfilgrastim	6000 μg/kg, day 2	Breast cancer	TA	[36]
09	Pegfilgrastim	30 μg/kg, day 2	NSCLC	CP	[33]
10	Pegfilgrastim	100 μg/kg, day 2	NSCLC	CP	[33]
11	Pegfilgrastim	300 μg/kg, day 2	NSCLC	CP	[33]
12	Pegfilgrastim	6000 μg/kg, day 2	NHL	CHOP-14	[37]
13	Pegfilgrastim	6000 μg/kg, day 2	DLBCL	R CHOP-14	[38]
14	-	-	NHL	CHOP-21* (young)	[39]
15	-	-	NHL	CHOP-21* (elderly)	[40]
16	-	-	NHL	CHOEP-21* (young)	[39]
17	-	-	NHL	CHOEP-21* (elderly)	[40]
18	-	-	HD	BEACOPP-21*	[41]
19	-	-	Breast cancer	EC-T*	[42]
20	Filgrastim	480 μg/kg, days 4-13	NHL	CHOP-14* (young)	[39]
21	Filgrastim	480 μg/kg, days 4-13	NHL	CHOP-14* (elderly)	[40]
22	Filgrastim	480 μg/kg, days 6-12	NHL	CHOP-14*	[43]
23	Filgrastim	480 μg/kg, days 4-13	NHL	CHOEP-14* (young)	[39]
24	Filgrastim	480 μg/kg, days 4-13	NHL	CHOEP-14* (elderly)	[40]
25	Filgrastim	480 μg/kg, days 6-13	NHL	high-CHOEP-21*	[43]
26	Filgrastim	480 μg/kg, days 8-13	HD	BEACOPP-14*	[44]
27	Filgrastim	480 μg/kg, days 8-15	HD	BEACOPP-21 escalated*	[41]
28	Filgrastim	480 μg/kg, days 3-10	Breast cancer	E-T-C*	[42]
29	Filgrastim	5 μg/kg, days 5-16	relapsed or persistent HD or NHL	ESHAP	[45]
30	Pegfilgrastim	6000 μg/kg, day 2	NHL	CHOP-14*	[46]
31	Pegfilgrastim	6000 μg/kg, day 4	NHL	CHOP-14*	[46]
32	Pegfilgrastim	100 μg/kg, day 6	relapsed or persistent HD or NHL	ESHAP	[45]
33	Pegfilgrastim	6000 μg/kg, day 2	DLBCL	R CHOP-14	[47]

Scenarios with access to raw data are denoted with*.

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