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Figure 3 | BMC Systems Biology

Figure 3

From: Insights from systems pharmacology into cardiovascular drug discovery and therapy

Figure 3

Relationships between cardiovascular targets and genes. (a) The average number of diseases associated with different gene classes from the gene-gene network (GG network): all genes, cardiovascular genes and genes that encode cardiovascular targets. (b) Average degree of different gene classes in the GG network. (c) The network only includes cardiovascular genes and genes that encode cardiovascular targets extracted from the overall GG network, in which two genes are connected if they are involved in the same disorder. This subnetwork shows that most genes that encode cardiovascular targets and cardiovascular genes gather into a complete network. Red, pink and green represent cardiovascular genes, genes that encode cardiovascular targets and overlapped genes, respectively. (d) Distribution of the shortest distances (green) between drug targets and disease genes in the GG network compared with that (tan) between random groups of genes. There is an enhancement at the distances 0 and 1. (e) Distribution of the shortest distances (yellow) between drug targets and disease genes in the GG network compared with that (blue) between random groups of genes.

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