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Figure 4 | BMC Systems Biology

Figure 4

From: Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs

Figure 4

GDI enables extremely long-term retention of the activation state of Rho GTPases. Simulation of Rho activation dynamics at K mGAP/GDI = 0.01, 01, and 1.0 μM in the presence of various free GDI concentrations (0–2.4 μM) in the GDI-integrated model. A) 600 min after stimulation. B) 12,000 min after stimulation. The activation levels of GTPases were expressed as the concentration of GTP-Rho/Effector complex.

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