Figure 1

Benchmark 2: sensitivities. The two panels on top show the local rank of the parameters, i.e., the parameters ordered in decreasing order of their influence on the system’s behaviour (\(\delta _{p}^{msqr}\), as defined in equations (9) and (10)). Note that the middle panel is a continuation of the upper one with a smaller y-axis scale. The array in the bottom panel shows the sensitivity of the 9 state variables (metabolite concentrations, in columns) of the model with respect to the 116 parameters. The colour bar in the right shows the sensitivity range: high sensitivities are plotted in red, low sensitivities in blue.