microRNAs’ differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN)

Table 2 Definition of efficient target and related effector process

miRNA’s regulation in stage 1	miRNA’s regulation in stage 2	Target’s contribution to a process in stage 1	Target’s contribution to a process in stage 2	Target definition	GO process definition
Exist	Not exist	Not exist	Exist	Efficient target	Related effector process
Not exist	Exist	Exist	Not exist	Efficient target	Related effector process

In this table, for an already detected Efficient Pair, we further analyze the accordance of miRNA regulation and target mRNA contribution to a process. As mentioned in context, the target’s contribution to a biological process is measured by the Efficient Score, if the Efficient Score is significant (p < 0.05), the mRNA’s contribution to the process is regarded as ‘exist’; elsewise, as ‘not exist’. For an Efficient Pair, if in one stage, miRNA’s repression on mRNA exists while mRNA’s contribution to the process does not exist; and in the other stage, miRNA’s repression on mRNA does not exist while mRNA’s contribution to the process exists, this target mRNA is defined as ‘Efficient Target’, and the corresponding process is defined as ‘Related Effector Process’. In summary, the Related Effector Process is significantly influenced by miRNA’s differential regulation, through the Efficient Target mediation.

ISSN: 1752-0509