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Table 3 Comparison of SIG++ method and permutation method from the number of identified miRNA — mRNA pairs

From: microRNAs’ differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN)

Data Cases of differential regulation Number of miRNA— mRNA Pairs Methods
SIG++ Permutation
Normal vs. CIN I Regulations exist in normal & not exist in CIN I N total 401 181
N AP 37 12
N TP 81 39
N EP = N AP + N TP 118(Set 1) 51
Regulations not exist in normal & exist in CIN I N total 129 266
N AP 20 38
N TP 9 15
N EP = N AP + N TP 29 (Set 2) 53
CIN I vs. CIN III Regulations exist in CIN I & not exist in CIN III N total 371 93
N AP 109 37
N TP 52 10
N EP = N AP + N TP 161 (Set 3) 47
Regulations not exist in CIN I & exist in CIN III Ntotal 107 65
NAP 6 3
NTP 9 6
NEP = NAP + NTP 15 (Set 4) 9
  1. This table lists the number of miRNA — mRNA pairs with significant regulation change detected by the SIG++ method and by the Permutation method, respectively. Ntotal: the number of detected differentially regulated miRNA — mRNA pairs whose targets have obvious expression change; NAP: the number of Agreement Pair (AP); NTP: the number of Typical Pair (TP); NEP: the number of Efficient Pair (EP). For the Efficient Pairs detected by the SIG++ algorithm, ‘Set 1’ refers to the set of EP whose regulation exist in normal stage and not exist in CIN I stage, ‘Set 2’ refers to the set of EP with regulation nonexistent in normal and existent in CIN I, ‘Set 3’ refers to the set of EP with regulation existent in CIN I and nonexistent in CIN III, and ‘Set 4’ refers to the set of EP with regulation nonexistent in CIN I and existent in CIN III.