TY - JOUR AU - Cole, John A. AU - Kohler, Lars AU - Hedhli, Jamila AU - Luthey-Schulten, Zaida PY - 2015 DA - 2015/03/18 TI - Spatially-resolved metabolic cooperativity within dense bacterial colonies JO - BMC Systems Biology SP - 15 VL - 9 IS - 1 AB - The exchange of metabolites and the reprogramming of metabolism in response to shifting microenvironmental conditions can drive subpopulations of cells within colonies toward divergent behaviors. Understanding the interactions of these subpopulations—their potential for competition as well as cooperation—requires both a metabolic model capable of accounting for a wide range of environmental conditions, and a detailed dynamic description of the cells’ shared extracellular space. SN - 1752-0509 UR - https://doi.org/10.1186/s12918-015-0155-1 DO - 10.1186/s12918-015-0155-1 ID - Cole2015 ER -