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Table 3 Summary of observations from model wild type and knockout simulations

From: Iron acquisition and oxidative stress response in aspergillus fumigatus

Condition

Strain

Long term model behavior

Cell

Cell

Support

Conflicts

  

ICP

ROS

Other interesting behavior

Growth

Death

  

O\(_{2}^{-}=0\)

wt

0.29

0.44

∙ TAFC = FC −Fe=0.52; high siderophore production

−

−

[5,8]

 
    

∙ Cat1/2 = 0.29; SOD2/3 = ThP = 0.44

  

prediction

 
    

∙ FC −Fe/FC +Fe=1.7

  

[14]

 

Fe 3+=0

hapX = 0

0

0

∙ SidA = 0

−

−

[29]

 
 

SidA = 0 or TAFC = 0

0

0

 

−

−

[5,8,33,52]

 
 

FC −Fe=0

0.11

0.43

 

−

−

[14,33]

 
 

EstB = 0 or MirB = 0

0

0

∙ TAFC = FC −Fe = 1; accumulation of siderophores

−

−

[55]

 
 

Yap1 = 0 or SOD2/3 = 0

0.29

1

 

−

+

 

[10,20]

O\(_{2}^{-}=0\)

wt

0.48

0.62

∙ TAFC = FC = 0.18; low siderophore production

+

−

[5,8]

 
    

∙ Cat1/2 = 0.54, SOD2/3 = ThP = 0.61

  

[13]

 
    

∙ FC −Fe/FC +Fe=1

  

[14]

 

Fe 3+=1

sreA = 0

1

1

∙ Derepression of hapX, RIA, CccA, & Cat1/2

+

+

[13,52]

 
    

∙ LIP = VAC = 1; iron overload

  

[13]

 
 

SidA = 0

0.42

0.61

 

+

−

[5,8,33]

 
 

RIA = 0

0.29

0.45

∙ SidA = 0.52; increased siderophore production

−

−

[8,33]

 
 

SidA = RIA = 0

0

0

 

−

−

[8,33]

 
 

Yap1 = 0 or SOD2/3 = 0

0.49

1

∙ Decreased resistance to Fe 3+

+

+

 

[10,20]

O\(_{2}^{-}=1\)

wt

0.28

0.78

∙ SOD2/3 = ThP = 0.76; Cat1/2 = 0.40

−

+

[20,33,61]

 
 

hapX = 0

0

0.58

∙ Derepressed Cat1/2 and increased resistance to O\(_{2}^{-}\)

−

−

prediction

 

Fe 3+=0

SidA = 0, TAFC = 0,

0

1

∙ Decreased resistance to O\(_{2}^{-}\)

−

+

prediction

 
 

MirB = 0 or EstB = 0

       
 

Yap1 = 0, SOD2/3 = 0,

0.29

1

∙ Decreased resistance to O\(_{2}^{-}\)

−

+

[9,10,20,61]

 
 

Cat1/2 = 0 or ThP = 0

       

O\(_{2}^{-}=1\)

wt

0.49

0.73

∙ FC −Fe/FC +Fe=1

+

+

[14,20,33]

 
    

∙ SOD2/3 = ThP = 0.73; Cat1/2 = 0.63

  

prediction

 

Fe 3+=1

sreA = 0

1

1

∙ Decreased resistance to Fe 3+

+

+

[13]

 
 

Yap1 = 0, SOD2/3 = 0,

0.47

1

∙ Decreased resistance to Fe 3+ and O\(_{2}^{-}\)

+

+

[9,20,61]

 
 

Cat1/2 = 0 or ThP = 0

       
  1. Numerical values in the ‘Long Term Model Behavior’ column represent SDMs. A − denotes low cell growth or low cell death, while a + denotes high cell growth or high cell death. Citations for supporting and conflicting literature are provided.