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Table 3 Summary of observations from model wild type and knockout simulations

From: Iron acquisition and oxidative stress response in aspergillus fumigatus

Condition Strain Long term model behavior Cell Cell Support Conflicts
   ICP ROS Other interesting behavior Growth Death   
O\(_{2}^{-}=0\) wt 0.29 0.44 ∙ TAFC = FC Fe=0.52; high siderophore production [5,8]  
     ∙ Cat1/2 = 0.29; SOD2/3 = ThP = 0.44    prediction  
     ∙ FC Fe/FC +Fe=1.7    [14]  
Fe 3+=0 hapX = 0 0 0 ∙ SidA = 0 [29]  
  SidA = 0 or TAFC = 0 0 0   [5,8,33,52]  
  FC Fe=0 0.11 0.43   [14,33]  
  EstB = 0 or MirB = 0 0 0 ∙ TAFC = FC Fe = 1; accumulation of siderophores [55]  
  Yap1 = 0 or SOD2/3 = 0 0.29 1   +   [10,20]
O\(_{2}^{-}=0\) wt 0.48 0.62 ∙ TAFC = FC = 0.18; low siderophore production + [5,8]  
     ∙ Cat1/2 = 0.54, SOD2/3 = ThP = 0.61    [13]  
     ∙ FC Fe/FC +Fe=1    [14]  
Fe 3+=1 sreA = 0 1 1 ∙ Derepression of hapX, RIA, CccA, & Cat1/2 + + [13,52]  
     ∙ LIP = VAC = 1; iron overload    [13]  
  SidA = 0 0.42 0.61   + [5,8,33]  
  RIA = 0 0.29 0.45 ∙ SidA = 0.52; increased siderophore production [8,33]  
  SidA = RIA = 0 0 0   [8,33]  
  Yap1 = 0 or SOD2/3 = 0 0.49 1 ∙ Decreased resistance to Fe 3+ + +   [10,20]
O\(_{2}^{-}=1\) wt 0.28 0.78 ∙ SOD2/3 = ThP = 0.76; Cat1/2 = 0.40 + [20,33,61]  
  hapX = 0 0 0.58 ∙ Derepressed Cat1/2 and increased resistance to O\(_{2}^{-}\) prediction  
Fe 3+=0 SidA = 0, TAFC = 0, 0 1 ∙ Decreased resistance to O\(_{2}^{-}\) + prediction  
  MirB = 0 or EstB = 0        
  Yap1 = 0, SOD2/3 = 0, 0.29 1 ∙ Decreased resistance to O\(_{2}^{-}\) + [9,10,20,61]  
  Cat1/2 = 0 or ThP = 0        
O\(_{2}^{-}=1\) wt 0.49 0.73 ∙ FC Fe/FC +Fe=1 + + [14,20,33]  
     ∙ SOD2/3 = ThP = 0.73; Cat1/2 = 0.63    prediction  
Fe 3+=1 sreA = 0 1 1 ∙ Decreased resistance to Fe 3+ + + [13]  
  Yap1 = 0, SOD2/3 = 0, 0.47 1 ∙ Decreased resistance to Fe 3+ and O\(_{2}^{-}\) + + [9,20,61]  
  Cat1/2 = 0 or ThP = 0        
  1. Numerical values in the ‘Long Term Model Behavior’ column represent SDMs. A − denotes low cell growth or low cell death, while a + denotes high cell growth or high cell death. Citations for supporting and conflicting literature are provided.