Figure 2

DSR-graphs of the running example.(A) The DSR-graph. There are two 4-nuclei corresponding to negative terms in the polynomial \(p_{A,Z_{1}}\): each of them consists of the red circuit combined with one of the two blue circuits. Of these, the only positive feedback loop is the red circuit, which is responsible for the observed multi-stationarity. (B) There are three positive feedback loops in the graph, marked with shades of grey. Only the self-activation feedback loop (red circuit in (A)) is associated a term in the polynomial \(p_{A,Z_{1}}\), see (14). Hence the other two positive feedback loops are not relevant for the observed multi-stationarity.