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Table 5 GPEA analysis of gene family gene sets for the UC RNAseq, Bead and Oligo GRN

From: Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data

Tag

Name

RNAseq

Bead

Oligo

CD

CD molecules

380/591/0

365/319/1.1e-140

351/319/8.9e-106

ZKRAB

Zinc fingers, C2H2-type with KRAB domain

338/764/0

306/289/5.3e-155

143/108/5.6e-64

RPL

L ribosomal proteins

59/119/1.2e-175

55/49/2.2e-59

44/72/3.4e-102

ZNF

Zinc fingers, C2H2-type

697/1307/0

641/515/4e-114

362/242/2.3e-53

HIST

Histones/Replication-dependent

67/236/0

61/154/5.7e-252

26/32/1.3e-48

HLA

Histocompatibility complex

24/46/1.1e-85

25/33/2.9e-57

19/22/9.1e-36

C1SET

Immunoglobulin superfamily/C1-set domain containing

38/51/1e-75

38/34/1.5e-46

37/26/1.1e-28

KLK

Kallikreins

17/26/1.2e-49

16/15/2.8e-26

14/14/1.7e-23

MT

Metallothioneins

14/12/3.5e-20

12/12/7.1e-23

10/10/3.5e-18

PCDHC

Cadherins/Protocadherins : Clustered

57/150/7.8e-242

56/24/6.6e-21

22/14/1.3e-17

IGD

Immunoglobulin superfamily/Immunoglobulin-like domain containing

233/175/3.6e-85

221/77/5.1e-22

177/67/2.6e-17

KRT

Keratins

55/87/1.4e-121

51/20/2.8e-17

35/20/1.5e-20

HOXL

Homeoboxes/ANTP class : HOXL subclass

52/54/1.6e-66

50/39/1.8e-46

43/20/5.2e-17

COLLAGEN

Collagens

46/37/3.4e-43

43/21/1.1e-21

33/17/5.5e-17

RPS

S ribosomal proteins

34/40/7.2e-59

32/14/3.1e-15

29/28/6.1e-38

PSM

Proteasome (prosome, macropain) subunits

45/25/4.1e-25

43/15/5e-13

42/26/7.7e-26

RBM

RNA binding motif (RRM) containing

209/114/2.6e-46

186/50/1.6e-12

151/72/2.3e-28

ENDOLIG

Endogenous ligands

230/77/7.9e-16

221/62/3.3e-13

192/62/2.8e-11

VSET

Immunoglobulin superfamily/V-set domain containing

161/95/1.4e-50

150/42/5.2e-14

110/33/9e-11

comI

Mitochondrial respiratory chain complex/Complex I

38/14/3.9e-12

38/12/2.6e-10

31/15/7.3e-15

UGT

UDP glucuronosyltransferases

20/15/4.8e-22

20/17/2.3e-27

7/5/1.4e-08

IFF2

Intermediate filaments type II, keratins (basic)

26/23/2.6e-33

24/8/3e-08

15/7/1.8e-08

comIV

Mitochondrial respiratory chain complex/Complex IV

16/13/8.5e-21

15/6/1.3e-07

12/7/6.3e-10

S100

S100 calcium binding proteins

21/12/1.1e-15

21/7/1.8e-07

17/7/1.1e-07

LNCRNA

Long non-coding RNAs

548/407/1.2e-78

468/168/2e-14

107/25/5.4e-06

complement

Complement system

35/18/3.8e-19

33/7/1e-04

30/9/9.6e-07

CYP

Cytochrome P450s

62/37/1.1e-33

56/10/0.00019

48/22/1.2e-17

SERPIN

Serine (or cysteine) peptidase inhibitors

36/21/2.1e-23

35/8/1.2e-05

30/7/0.00031

  1. Shown are the commonly significant gene family subnetworks of the RNAseq, Bead and Oligo UC GRN, number of genes of the gene family subnetwork, the number of interactions and the Bonferroni adjusted P-value (Genes/Interactions/P-value).