Table 6 The six major hub genes for the RNAseq, Bead and Oligo UC GRN

Gene

Degree

Locus

Description/GO

Cancer association

Cancer

Ref

HID1 (DMC1)

139

chr17q25.1

Transmembrane

Downregulated

Breast, cervix, liver, lung,

[53]

thyroid, stomach, kidney

FER1L4

135

20q11.22

lncRNA

Downregulated

Stomach

[54,81]

TTLL3

128

3p25.3

Tubulin-tyrosine

Downregulated

Colon

[55,82]

ligase activity

RIF1

126

2q23.3

DNA repair

Anti-apoptotic

Breast

[56]

KLHDC7A (FLJ38753)

116

1p36.13

Transmembrane

-

-

-

SBNO1

110

12q24.31

DNA binding

Proliferation

Lung

[57]

B) Bead UC GRN

Gene

Degree

Locus

Description/GO

Cancer association

Cancer

Ref

MGC15885

119

15q22.2

ncRNA

-

-

-

RNF17 (TDRD4)

107

13q12.12

Spermatid development

Potential cancer CT antigen

Liver

[58]

OR6S1

105

14q11.2

G-protein coupled

-

-

-

receptor signaling pathway

ACTR3BP5

104

10p11.1

Pseudogene

-

-

-

TPTE2P3

98

13q14.3

Pseudogene

-

-

-

TMED7

90

5q22.3

Protein transport

Upregulated

Nasopharynx carcinoma

[59]

cell line

C) Oligo UC GRN

Gene

Degree

Locus

Description/GO

Cancer association

Cancer

Ref

CYP4A11

184

1p33

Monooxygenase activity

Promotes angiogenesis

Lung

[60]

and metastasis

GJC2

162

1q42.13

Gap junction channel

-

-

-

activity

GPATCH4

147

1q23.1

Nucleic acid binding

-

-

-

ADAM5

141

8p11.22

Metalloendopeptidase

-

-

-

activity, pseudogene

DKFZP434A062

120

9q34.3

Uncharacterized protein

-

-

-

SLC38A3 (SNAT3)

118

3p21.31

Symporter activity

malignancy marker

Glioma

[61]