Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Reyes-Gibby, Cielito C.; Yuan, Christine; Wang, Jian; Yeung, Sai-Ching J.; Shete, Sanjay

doi:10.1186/s12918-015-0167-x

Table 2 Summary of literature search - smoking addiction

From: Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Author	Ethnicity	Sample size	Phenotype	Salient gene(s)	Salient SNP(s)	Statistical analysis
Agrawal et al. [96]	EA	1929	Nicotine dependence	GABRA4, GABRA2, GABRE		P = 0.030
Agrawal et al. [97]	EA	1921	Nicotine dependence	GABRA4, GABRA2		P = 0.002
Anney et al. [98]	E	815	Cigarette dose	CHRM5	rs7162140	P = 0.01
Baker et al. [31]	EA	886	Nicotine dependence	CHRNA5-A3-B4		P = 0.04
Berrettini et al. [99]	EA	1276	Nicotine addiction	CYP2A6	rs410514431	P = 1.0E-12
Beuten et al. [100]	EA, AA	2037	Nicotine dependence	BDNF	rs6484320 rs988748 rs2030324 rs7934165	P = 0.002
Beuten et al. [101]	EA, AA		Nicotine dependence	GABAB2	rs2491397 rs2184026 rs3750344 rs1435252 rs378042 rs2779562 rs3750344	P = 0.003
Beuten et al. [102]	EA, AA		Nicotine dependence	COMT	rs933271 rs4680 rs174699	P = 0.0005
Broms et al. [32]	E	1428	Nicotine dependence	CHRNA5, CHRNA3, CHRNB4	rs2036527 rs578776 rs11636753 rs11634351 rs1948 rs2036527	P = 0.000009, 0.0001, 0.0059, 0.0069, 0.0071, 0.0003
Chen et al. [103]		688	Nicotine dependence	CNR1	rs2023239 rs12720071 rs806368	P < 0.001
Chen et al. [79]	EA, AA	3627	Nicotine addiction	PKNOX2	rs1426153 rs11220015 rs11602925 rs750338 rs12273605 rs10893365 rs10893366 rs12284594	P = 0.0159, 0.0163, 0.0136, 0.0491, 0.0921, 0.0411, 0.0621, 0.0239
Conlon et al. [33]	EA	1122	Nicotine dependence	CHRNA5, CHRNA3, AGPHD1	rs16969968 rs578776 rs8034191	OR = 3.2, 2.8, 0.3
Culverhouse et al. [34]	AA, EA	18500	Nicotine dependence	CHRNB3, CHRNA7	rs13273442	P = 0.00058 for EA, 0.05 for AA
Docampo et al. [104]	E	752	Lower risk for smoking behavior	NRXN3	rs1424850 rs221497 rs221473	rs1424850: OR = 0.55, P = 0.0002
						rs221497: OR = 0.47, P = 0.0020
						rs221473: OR = 0.54, P = 0.0009
Ehringer et al. [35]	EA, Hisp, AA	108	Nicotine response	CHRNB2	rs2072658
Ella et al. [105]	Japanese	2521	Nicotine addiction	DBH	rs5320	P = 0.030
Gabrielsen et al. [36]	Norwegian	155941	Smoking status(cigarettes per day, duration, packs per year)	CHRNA5/A3/B4	rs16969968	P = 3.15E-25, 1.11E-6, 3.01E-23 (respectively for phenotypes)
Huang et al. [106]	EA, AA	3403	Nicotine dependence	ANKK1	rs2734849	P = 0.0026
Lang et al. [107]	E	320	Smoking behavior	BDNF		P = 0.045
Li et al. [38]	EA, AA	2037	Nicotine dependence	CHRNA4	rs2273504 rs1044396 rs3787137 rs2236196
Liu et al. [108]	EA, AA	2091	Smoking behavior	IL15	rs4956302	P = 8.8E-8
Ma et al. [109]	EA, AA	2037	Nicotine dependence	DDC	rs3735273 rs1451371 rs3757472 rs3735273 rs1451371 rs2060762	P = 0.005, 0.006
Mobascher et al. [110]	German	5500	smoking behavior/nicotine addiction	CHRM2	rs324650	OR = 1.17
Nees et al. [39]	E, EA	965	Nicotine dependence	CHRNA5/A3/B4	rs578776	P < 0.05
Sherva et al. [40]	EA, AA	435	Smoking	CHRNA5	rs16969968	P = 0.0001
Rice et al. [29]	EA, AA	3365	Nicotine dependence	CHRNB3	rs1451240	P = 2.4E-8
Sarginson et al. [30]	EA, Asian, AA, Hispanic	577	Smoking behavior	CHRNA5/A3/B4	rs16969968 rs1051730	P < 0.0001
Sorice et al. [41]	E	2272	Smoking behavior	CHRNA5-A3-B4	rs1051730	P = 0.0151, 0.022, 0.22 for three populations
Voisey et al. [52]	EA	378	Nicotine dependence	DRD2	rs1800497	P = 0.0003
Wang et al. [43]	EA, AA	3622	ND (smoking quantity and FTND)	CHRNA2, CHRNA6	EA: rs3735757 rs2472553	EA: P = 0.0068 for FTND, AA: P = 0.0043 for SQ and 0.00086 for FTND
Wassenaar et al. [44]	E	860	Nicotine dependence	CYP2A6 and CHRNA5-A3-B4	rs1051730	P =0.036
Weiss et al. [45]	E	2827	Nicotine dependence	CHRNA5-A3-B4	rs17486278	P = 0.0005
Zeiger et al. [46]	EA, Hisp	1056	Response to smoking	CHRNA6, CHRNB3	rs4950 rs13280604 rs2304297	P = 0.043, 0.011, 0.053

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