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Table 2 Summary of literature search - smoking addiction

From: Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Author Ethnicity Sample size Phenotype Salient gene(s) Salient SNP(s) Statistical analysis
Agrawal et al. [96] EA 1929 Nicotine dependence GABRA4, GABRA2, GABRE   P = 0.030
Agrawal et al. [97] EA 1921 Nicotine dependence GABRA4, GABRA2   P = 0.002
Anney et al. [98] E 815 Cigarette dose CHRM5 rs7162140 P = 0.01
Baker et al. [31] EA 886 Nicotine dependence CHRNA5-A3-B4   P = 0.04
Berrettini et al. [99] EA 1276 Nicotine addiction CYP2A6 rs410514431 P = 1.0E-12
Beuten et al. [100] EA, AA 2037 Nicotine dependence BDNF rs6484320 rs988748 rs2030324 rs7934165 P = 0.002
Beuten et al. [101] EA, AA   Nicotine dependence GABAB2 rs2491397 rs2184026 rs3750344 rs1435252 rs378042 rs2779562 rs3750344 P = 0.003
Beuten et al. [102] EA, AA   Nicotine dependence COMT rs933271 rs4680 rs174699 P = 0.0005
Broms et al. [32] E 1428 Nicotine dependence CHRNA5, CHRNA3, CHRNB4 rs2036527 rs578776 rs11636753 rs11634351 rs1948 rs2036527 P = 0.000009, 0.0001, 0.0059, 0.0069, 0.0071, 0.0003
Chen et al. [103]   688 Nicotine dependence CNR1 rs2023239 rs12720071 rs806368 P < 0.001
Chen et al. [79] EA, AA 3627 Nicotine addiction PKNOX2 rs1426153 rs11220015 rs11602925 rs750338 rs12273605 rs10893365 rs10893366 rs12284594 P = 0.0159, 0.0163, 0.0136, 0.0491, 0.0921, 0.0411, 0.0621, 0.0239
Conlon et al. [33] EA 1122 Nicotine dependence CHRNA5, CHRNA3, AGPHD1 rs16969968 rs578776 rs8034191 OR = 3.2, 2.8, 0.3
Culverhouse et al. [34] AA, EA 18500 Nicotine dependence CHRNB3, CHRNA7 rs13273442 P = 0.00058 for EA, 0.05 for AA
Docampo et al. [104] E 752 Lower risk for smoking behavior NRXN3 rs1424850 rs221497 rs221473 rs1424850: OR = 0.55, P = 0.0002
rs221497: OR = 0.47, P = 0.0020
rs221473: OR = 0.54, P = 0.0009
Ehringer et al. [35] EA, Hisp, AA 108 Nicotine response CHRNB2 rs2072658  
Ella et al. [105] Japanese 2521 Nicotine addiction DBH rs5320 P = 0.030
Gabrielsen et al. [36] Norwegian 155941 Smoking status(cigarettes per day, duration, packs per year) CHRNA5/A3/B4 rs16969968 P = 3.15E-25, 1.11E-6, 3.01E-23 (respectively for phenotypes)
Huang et al. [106] EA, AA 3403 Nicotine dependence ANKK1 rs2734849 P = 0.0026
Lang et al. [107] E 320 Smoking behavior BDNF   P = 0.045
Li et al. [38] EA, AA 2037 Nicotine dependence CHRNA4 rs2273504 rs1044396 rs3787137 rs2236196  
Liu et al. [108] EA, AA 2091 Smoking behavior IL15 rs4956302 P = 8.8E-8
Ma et al. [109] EA, AA 2037 Nicotine dependence DDC rs3735273 rs1451371 rs3757472 rs3735273 rs1451371 rs2060762 P = 0.005, 0.006
Mobascher et al. [110] German 5500 smoking behavior/nicotine addiction CHRM2 rs324650 OR = 1.17
Nees et al. [39] E, EA 965 Nicotine dependence CHRNA5/A3/B4 rs578776 P < 0.05
Sherva et al. [40] EA, AA 435 Smoking CHRNA5 rs16969968 P = 0.0001
Rice et al. [29] EA, AA 3365 Nicotine dependence CHRNB3 rs1451240 P = 2.4E-8
Sarginson et al. [30] EA, Asian, AA, Hispanic 577 Smoking behavior CHRNA5/A3/B4 rs16969968 rs1051730 P < 0.0001
Sorice et al. [41] E 2272 Smoking behavior CHRNA5-A3-B4 rs1051730 P = 0.0151, 0.022, 0.22 for three populations
Voisey et al. [52] EA 378 Nicotine dependence DRD2 rs1800497 P = 0.0003
Wang et al. [43] EA, AA 3622 ND (smoking quantity and FTND) CHRNA2, CHRNA6 EA: rs3735757 rs2472553 EA: P = 0.0068 for FTND, AA: P = 0.0043 for SQ and 0.00086 for FTND
Wassenaar et al. [44] E 860 Nicotine dependence CYP2A6 and CHRNA5-A3-B4 rs1051730 P =0.036
Weiss et al. [45] E 2827 Nicotine dependence CHRNA5-A3-B4 rs17486278 P = 0.0005
Zeiger et al. [46] EA, Hisp 1056 Response to smoking CHRNA6, CHRNB3 rs4950 rs13280604 rs2304297 P = 0.043, 0.011, 0.053