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Table 3 Summary of literature search - opioid addiction

From: Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Author Ethnicity Sample size Phenotype Salient gene(s) Salient SNP(s) Statistical analysis
Beer et al. [22] E 284 Opioid dependence GAL, OPRD1 rs948854 rs2236861 P = 0.001
Bunten et al. [23]   184 Opioid addiction OPRM1 rs1799971 P = 0.0046
Compton et al. [24] EA 109 Opioid addiction OPRM1 rs1799971  
Clarke et al. [111] Han Chinese 858 Opioid dependence PDYN rs1997794 rs1022563 P = 0.019, 0.006
Clarke et al. [48] EA, AA 992 Opioid addiction DRD2 rs1076560 OR = 1.29, P = 0.0038
Crist et al. [112] EA, AA 671 Opioid addiction WLS rs3748705 (AA) rs983034 rs1036066 (EA) AA: P = 0.025EA: P = 0.043, 0.045
de Cid et al. [113] E 91 Opioid Addiction BDNF   
Doehring et al. [49] CA 184 Opioid addiction DRD2 rs1076560 rs1799978 rs6277 rs12364283 rs1799732 rs6468317 rs6275 rs1800498 rs1800497 P = 0.022, 0.048
Gelernter et al. [114] EA, AA 8246 Opioid dependence KCNG2 rs62103177 P = 3.60E-10
Herman et al. [115] EA, AA 1367 Opioid dependence CNR1 rs6928499 rs806379 rs1535255 rs2023239  
Ho et al. [50] Chinese 252 Opioid dependence DRD4   P = 0.041
Kumar et al. [116] South Asian 260 Opioid dependence CREBBP rs3025684 P < 0.0001
Kumar et al. [26] Bengali/Hindu 330 Opioid addiction OPRM1 rs16918875 rs702764 rs963549 P = 0.0264
Levran et al. [117]   74 Opioid addiction CYP2B6   
Liu et al. [118] African 3627 Opioid addiction NCK2 rs2377339 P = 1.33E-11
Nagaya et al. [28] Asian 160 Opioid addiction OPRM1 rs1799972 OR = 1.77, P < 0.0001
Zhu et al. [53] Chinese 939 Opioid dependence/addiction DRD1 rs686 P = 0.0003