Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

Table 3 Summary of literature search - opioid addiction

Author	Ethnicity	Sample size	Phenotype	Salient gene(s)	Salient SNP(s)	Statistical analysis
Beer et al. [22]	E	284	Opioid dependence	GAL, OPRD1	rs948854 rs2236861	P = 0.001
Bunten et al. [23]		184	Opioid addiction	OPRM1	rs1799971	P = 0.0046
Compton et al. [24]	EA	109	Opioid addiction	OPRM1	rs1799971
Clarke et al. [111]	Han Chinese	858	Opioid dependence	PDYN	rs1997794 rs1022563	P = 0.019, 0.006
Clarke et al. [48]	EA, AA	992	Opioid addiction	DRD2	rs1076560	OR = 1.29, P = 0.0038
Crist et al. [112]	EA, AA	671	Opioid addiction	WLS	rs3748705 (AA) rs983034 rs1036066 (EA)	AA: P = 0.025EA: P = 0.043, 0.045
de Cid et al. [113]	E	91	Opioid Addiction	BDNF
Doehring et al. [49]	CA	184	Opioid addiction	DRD2	rs1076560 rs1799978 rs6277 rs12364283 rs1799732 rs6468317 rs6275 rs1800498 rs1800497	P = 0.022, 0.048
Gelernter et al. [114]	EA, AA	8246	Opioid dependence	KCNG2	rs62103177	P = 3.60E-10
Herman et al. [115]	EA, AA	1367	Opioid dependence	CNR1	rs6928499 rs806379 rs1535255 rs2023239
Ho et al. [50]	Chinese	252	Opioid dependence	DRD4		P = 0.041
Kumar et al. [116]	South Asian	260	Opioid dependence	CREBBP	rs3025684	P < 0.0001
Kumar et al. [26]	Bengali/Hindu	330	Opioid addiction	OPRM1	rs16918875 rs702764 rs963549	P = 0.0264
Levran et al. [117]		74	Opioid addiction	CYP2B6
Liu et al. [118]	African	3627	Opioid addiction	NCK2	rs2377339	P = 1.33E-11
Nagaya et al. [28]	Asian	160	Opioid addiction	OPRM1	rs1799972	OR = 1.77, P < 0.0001
Zhu et al. [53]	Chinese	939	Opioid dependence/addiction	DRD1	rs686	P = 0.0003

ISSN: 1752-0509