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Table 4 Overlapping genes for networks of nicotine, alcohol and opioid addiction; focus genes from literature are bolded

From: Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction

A: Opioids ∩ Alcohol B: Opioids ∩ Nicotine C: Opioids ∩ Alcohol ∩ Nicotine
Molecule Edges in opioid network/edges in alcohol network Molecule Edges in opioid network/edges in nicotine network Molecule Edges in opioid network/edges in alcohol network/edges in nicotine network
NFkB (complex) 112/86 ERK1/2 74/76 ERK1/2 74/62/76
ERK1/2 74/62 ARRB2 8/3 DRD2 6/3/4
IL1R1 7/4 DRD2 6/4 TAP1 5/5/3
IL1 6/8 HSPD1 5/4 SAA 4/3/4
DEFB4A/DEFB4B 6/4 TAP1 5/3 PSMB9 4/3/3
DRD2 6/3 SAA 4/4 TAPBP 4/3/3
ELANE 5/6 PSMB9 4/3 ELF3 4/3/2
F2RL1 5/6 TAPBP 4/3 TAC1 4/3/2
TAP1 5/5 ELF3 4/2 CLEC11A 3/4/2
F2R 5/3 TAC1 4/2 SMPD2 3/3/3
ADRBK1 5/2 PSMB10 3/3 CXCL3 3/3/2
Ikb 4/4 SMPD2 3/3 P2RY6 3/3/2
CXCL2 4/3 AKAP13 3/2 PSMB10 3/2/3
ELF3 4/3 CLEC11A 3/2 AKAP13 3/2/2
FPR2 4/3 CXCL3 3/2 TLR6 3/2/2
PSMB9 4/3 P2RY6 3/2 CRHR1 2/4/3
SAA 4/3 TLR6 3/2 CD244 2/3/3
TAC1 4/3 CD244 2/3 CXCL5 2/3/2
TAPBP 4/3 CRHR1 2/3 CCL21 2/2/2
DEFB103A/DEFB103B 4/2 CCL21 2/2 GMFG 2/2/2
LTF 3/5 CNR1 2/2   
TNFSF11 3/5 CXCL5 2/2   
TNFSF15 3/5 GMFG 2/2   
CLEC11A 3/4 GPRASP1 2/2   
TLR1 3/4 BDNF 2/1   
CXCL3 3/3     
KLF6 3/3     
P2RY6 3/3     
SMPD2 3/3     
AKAP13 3/2     
ARF6 3/2     
IER3 3/2     
PSMB10 3/2     
TLR6 3/2     
TRPC6 3/2     
CRHR1 2/4     
CCL22 2/3     
CD244 2/3     
CXCL5 2/3     
CC2D1A 2/2     
CCL21 2/2     
GMFG 2/2     
SH3GLB2 2/2     
STAB2 2/2     
TSC22D3 2/2     
OPRM1 1/2