Fig. 5

Prediction of effect of multiple vaccinations with enhanced T cell cytotoxic ability and saturation constant. The simulation results were obtained with enhanced T cell saturation constant α=7.82349×10¹¹ and T cell cytotoxic ability c ₄=37350 and the rest of parameters as listed in Table 1. To examine the impact of the frequency of vaccination with enhanced T cell cytotoxic ability and saturation constant, model predictions were obtained with adenovirus vaccination with dose of 1×10⁶ RLU per mm³ every 5 days for 1 time (purple lines), 5 times (green lines), 10 times (red lines) post the one time vaccination on day 5 after tumor implantation with dosage 1×10⁶ RLU per mm³ in the experiment. a TE1, b TE2, c TE3, d LV, e Total tumor cells (CMHCI+ + CMHCI-), f IFNG, g TNFA, and h TN