|
k
d1
|
d
a
y
−1
|
Naïve CD8 + T cell natural death rate constant
|
3.809×10−3
|
|
k
d2
|
d
a
y
−1
|
Adenovirus natural death rate constant
|
0.364
|
|
k
d3
|
d
a
y
−1
|
Blood T effector natural death rate constant
|
1.80×10−2
|
|
k
d4
|
d
a
y
−1
|
Tumor cell natural death rate constant
|
2.08×10−6
|
|
k
d5
|
d
a
y
−1
|
Tumor T effector natural death rate constant
|
0.800
|
|
k
d6
|
d
a
y
−1
|
Interferon γ natural degradation rate constant
|
0.082
|
|
k
d7
|
d
a
y
−1
|
Tumor Necrosis Factor α natural degradation rate constant
|
3.10×10−6
|
|
k
p1
|
d
a
y
−1
|
Lymph node T effector proliferation rate constant due to adenovirus vaccination
|
12.017
|
|
k
p2
|
d
a
y
−1
|
Tumor cell proliferation rate constant
|
0.5
|
|
k
p3
|
d
a
y
−1
|
Tumor T effector proliferation rate constant due to tumor growth
|
5.73×10−6
|
|
a
12
|
d
a
y
−1
|
Rate constant for T cell flow from lymph node to blood
|
5.706
|
|
a
21
|
d
a
y
−1
|
Rate constant for T cell flow from blood to lymph node
|
3.540×10−3
|
|
a
23
|
d
a
y
−1
|
Rate constant for T cell flow from blood to tumor
|
5.546×10−2
|
|
a
32
|
d
a
y
−1
|
Rate constant for T cell flow from tumor to blood
|
6.89×10−18
|
|
c
1
|
c
e
l
l·m
m
−3·d
a
y
−1
|
Naïve T cell natural production rate
|
2.719×10−4
|
|
c
2
|
d
a
y
−1
|
T cell to lymph node T effector transfer rate constant
|
0.5263
|
|
c
3
|
d
a
y
−1
|
MHC class I negative to positive tumor cells transfer rate constant
|
0.8759
|
|
c
4
|
m
m
3·d
a
y
−1
|
MHCI positive tumor death rate due to T effector (in tumor) lysis
|
2.49×10−13
|
|
α
|
(c
e
l
l·m
m
−3)2
|
Lymph node T effector saturation constant
|
6.520×1010
|
|
k
1
|
m
o
l
e
s·m
m
−3
|
Interferon γ saturation constant
|
3.69×10−9
|
|
k
2
|
m
o
l
e
s·m
m
−3
|
Tumor Necrosis Factor α saturation constant
|
6.924×106
|
|
k
3
|
m
o
l
e
s·d
a
y
−1·c
e
l
l
−1
|
Constitutive Tumor Necrosis Factor α production rate constant
|
2.634×10−4
|
|
k
c1
|
m
o
l
e
s·d
a
y
−1·c
e
l
l
−1
|
Cellular Interferon γ production rate constant
|
7.295×108
|
|
k
c2
|
m
o
l
e
s·d
a
y
−1·c
e
l
l
−1
|
Autocrine Tumor Necrosis Factor α production rate constant
|
9.939×108
|
|
γ
|
R
L
U·m
m
−3
|
Adenovirus saturation constant
|
2.905×103
|
|
β
1
|
AU
|
Constant of proportionality in calculating T
C
R
α
gene expression
|
8.79×10−6
|
|
r
2
|
c
e
l
l
−1·d
a
y
−1
|
Constant in tumor logistic growth (or MHC class I negative tumor growth rate divided by the carrying capacity K, i.e., \(\frac {k_{p2}-k_{d4}}{K}\))
|
3.34×10−10
|
