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Fig. 7 | BMC Systems Biology

Fig. 7

From: Increased robustness of early embryogenesis through collective decision-making by key transcription factors

Fig. 7

Developmental bifurcations are governed by a hierarchical regulatory circuitry. Each circuit consists of two clusters of transcription factors (TFs), with positive feedbacks within each cluster and negative feedbacks between the two clusters. Prior to each developmental bifurcation, the TFs of both corresponding clusters are expressed at a balanced state. In each post-bifurcation branch, one cluster is downregulated while the other is upregulated. This triggers the competitive expression of clusters that switch later bifurcations

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