Increased robustness of early embryogenesis through collective decision-making by key transcription factors

BMC Systems Biology

Table 1 Examples of two-TF regulatory circuits that are suggested for lineage bifurcations

TF1	TF2	Progenitor	Lineage 1	Lineage 2	Ref.
TF1	TF2	(TF1 ≈ TF2)	(TF1 > TF2)	(TF1 < TF2)	Ref.
Gata1	Pu.1	Common myeloid progenitor	Erythroid	Myeloid	[3]
Oct4	Cdx2	Totipotent embryonic cells	Inner cell mass	Trophectoderm	[12]
Nanog	Gata4/6	Inner cell mass	Epiblast	Primitive endoderm	[13]
Sox10	Phox2b	Bipotential neural progenitor	Glia	Neuron	[54]
Ptf1a	Nkx6	Pancreatic progenitor	Exocrine cells	Endocrine cells	[55]
Pax3	Foxc2	Dermomyotome progenitor	Myogenic cells	Vascular cells	[55]

ISSN: 1752-0509