Fig. 1
From: Distinguishing the rates of gene activation from phenotypic variations
Schematic representation of the genetic switching model with positive feedback. a Four-state model. A single regulatory protein can bound to the DNA and improve the efficiency of chromatin opening. When the chromatin is open, mRNA is synthesized and will later be translated into a regulatory protein. The four states of DNA are (i) closed and unbounded, (ii) closed and bounded, (iii) open and unbounded, (iv) open and bounded. The switches between the adjacent states are reversible. b Simplified two-state model. Binding/unbinding is reduced through the QSSA