Fig. 3
From: Systems biology surveillance decrypts pathological transcriptome remodeling
Physiological systems impacted by CALR−/−-NP. Quality control of the CALR−/−-NP transcriptome revealed enrichment of specific physiological systems. a Volcano plot analysis identifies genes up or down regulated by more than 2-fold versus control. Orange circles represent genes that meet or exceed the ±2 fold-change criteria (vertical green lines) and satisfy the P-value threshold of P ≤ 0.05 (horizontal green line indicates P = 0.05). b Significance plot using –log (P-value) reveals Cardiovascular System Development and Function as the most significantly represented developmental system impacted by NP truncation independent of up and down regulated sub-transcriptome cohorts