Table 2 Categorical enrichment of network functions, disease classifications and/or dysregulated biological themes in the PC truncation variant
From: Systems biology surveillance decrypts pathological transcriptome remodeling
Up regulated | Down regulated |
Top Networks | |
Cellular Assembly and Organization, Molecular Transport, RNA Trafficking | Cellular Assembly and Organization, Cellular Function and Maintenance, Hematological System Development and Function |
RNA Post-Transcriptional Modification, Embryonic Development, Organismal Development | Cell Signaling, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair |
Cell Cycle, Cellular Development, Cell Morphology | Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry |
Cellular Function and Maintenance, Cellular Movement, Nervous System Development and Function | Cell Death and Survival, Hematological System Development and Function, Immune Cell Trafficking |
Nervous System Development and Function, Cell Cycle, Digestive System Development and Function | Cell Morphology, Nervous System Development and Function, Cell-to-cell Signaling and Interaction |
Top Diseases and Bio Functions | |
Cancer | Cancer |
Gastrointestinal Disease | Cardiovascular Diseasea |
Infectious Disease | Organismal Injury and Abnormalities |
Neurological Disease | Dermatological Diseases and Conditions |
Developmental Disorder | Developmental Disorder |